Double trouble! Panthers left cursing their luck following injuries for TWO of their halfbacks - including superstar number seven Nathan Cleary

They are the undoubted yardstick of the NRL - but Panthers staff, players and fans were left cursing their luck on Friday following injuries to halfbacks Nathan Cleary and fill-in Brad Schneider.

While Cleary tweaking his hamstring could prove to be dire for the NSW Blues ahead of the State of Origin series opener on June 5, Penrith coach Ivan Cleary declared the 'show goes on.'

'He's pretty shattered actually, it's very disappointing for him. Obviously I'm torn between being his coach and his Dad right now,' the Panthers coach said in the post-match press conference.

'I thought in that first half he was really starting to come into his own. But yeah anyway, the show goes on.

'He sort of did it sprinting on a kick and diving....'He [then] felt it straight away so he knew, that would suggest it's decent.'

In the earlier NSW Cup clash with the Bulldogs, Schneider - who was recruited by the club in the off-season as a back up for Cleary -   injured his knee following an ugly charge down attempt.

Cleary spoke for many Panthers fans when he lamented 'we've lost two in one night.'

Scans will determine the severity of Cleary's hamstring complaint - and his coach is bracing himself for bad news.

He also wouldn't rule out sending the playmaker abroad to work with US based rehab expert Bill Knowles.

'It's a concern yes, but I'm not qualified to make certain [medical] judgements,' Cleary said.

'We will treat it on its merits and go from there.'