Kevin De Bruyne has been benched for Manchester City's Champions League game at Real Madrid on Tuesday after 'vomiting' in the changing room.
Pep Guardiola's side made four changes from the side that beat Crystal Palace on Saturday, but the most eye-catching is the omission of the Belgian.
Rico Lewis, Julian Alvarez and Oscar Bobb also miss out, with Manuel Akanji, Bernardo Silva, Phil Foden and Mateo Kovacic coming in for the Bernabeu clash.
On De Bruyne, Guardiola told TNT Sports: 'Vomits. He feels unwell. I don't know, we make a meeting and we he was ready, when we arrive in the locker room starts to vomit and say he's not ready.'
The 14-times winners of Europe's biggest club competition host the current holders of the Champions League crown, after Man City's success last summer.
Kevin De Bruyne is on the bench for Manchester City's game at Real Madrid on Tuesday night
Pep Guardiola revealed that the Belgian was vomiting in the changing room before the game
The roof will be closed at the Bernabeu, as the hosts look to create an intimidating atmosphere against Guardiola's side.
Speaking in Monday's press conference, Real Madrid boss Carlo Ancelotti said he was 'very nervous' ahead of the game against Manchester City.
The Italian added: 'The hours before a match are a time when you have to suffer.
'I was thinking the other day that defeat is suffering and victory is happiness, but it's not that way. Victory is relief.
The roof will be closed at the Bernabeu as the hosts look to create an intimidating atmosphere
'It's happiness if you win trophies, but an isolated victory is a relief.
'You're calmer and happier the days after, but suffering is part of your job. It's what keeps you alive. It's fuel for me.'