New Farm Brisbane: Inner-city suburb rocked by explosion as house fire badly burns two people with three others treated for smoke inhalation

At least 10 fire crews have rushed to the scene of a house fire which caused an explosion in an inner-city suburb of Brisbane.

Residents reported hearing an explosion on the corner of Bowen Terrace and Oxley Lane, New Farm around 9.15am on Saturday morning.

On arrival emergency services discovered two people badly burnt who were transported to hospital in a serious condition.

Three more people were treated for smoke inhalation. 

On Facebook Queensland Ambulance Service said the blaze, initially described as 'out of control', had now been contained.

Motorists are advised to drive with caution and to conditions. Residents are advised to close windows and doors and, if needed, keep respiratory medications nearby. 

Police have established a crime scene.

More to come.