Friends' star Matthew Perry died from the accidental effects of ketamine and drowning, his autopsy revealed.
'The County of Los Angeles Department of Medical Examiner determined the cause of death for 54-year-old actor Matthew Langford Perry as the acute effects of ketamine,' the Los Angeles coroner's office said on Friday.
'Contributing factors in Mr Perry’s death include drowning, coronary artery disease and the effects of buprenorphine (used to treat opioid use disorder). The manner of death is accident.'
Perry, 54, was found dead at his Los Angeles home at 4.17pm on October 28, stunning the world of showbiz and breaking the hearts of fans worldwide.
Friends' star Matthew Perry was killed by ketamine and drowning, with his death ruled an accident. He is pictured on October 22 - the last time he was seen in public
In his last post to his Instagram, posted the week he died, the star shared images of him in his pool
He was declared dead at the scene and the medical examiner conducted the autopsy on October 29.
Months before his death he released a tell-all memoir that included shocking details of his drug and alcohol addiction.
But he said in October 2022 that he was 18 months sober, though that was a year before his death.
Those who knew him maintain Perry was clean and sober at the time of his death.
When investigators responded to Perry's home, they did not find any illegal drugs, but found prescription medication that was properly labeled and kept in storage bottles.
The Batman logo at the bottom of his pool can be seen here in an aerial daylight shot
Police officers taped off the street leading to Matthew Perry's house where he was found dead on October 28
The memoir, Friends, Lovers and the Big Terrible Thing, Perry wrote that after his colon exploded in 2018, he was prescribed opiates that he deemed insufficient to deal with his pain.
This prompted him to turn to street dealers to supply him with potentially fatal fentanyl-laced OxyContin.
'The street pills were something like $75 per pill, so I was giving the guy $3,000 at a time, many times a week,' he wrote.
Perry wrote that he spent $9 million trying to get sober, going to 6,000 AA meetings, 15 times to rehab, and was in detox 65 times.
He said he overcame addiction in 2021 and was leading a healthier lifestyle.
Matthew Perry died of the acute effects of ketamine combined with drowning, Los Angeles' coroners office has revealed
He took up pickle ball - a game similar to tennis and table tennis - and usually played it twice a day, friends said.
Perry was found underwater by his assistant who lifted his head up to try to get him some air, first responders earlier revealed.
Captain Erik Scott, with the LAFD said: 'Los Angeles City Firefighters responded [and] found an adult male unconscious in a stand-alone hot tub.
'A bystander had brought the man's head above the water and gotten him to the edge, then firefighters removed him from the water upon their arrival.
'A rapid medical assessment, sadly, revealed the man was deceased prior to first responder arrival.'